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Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles. The highly positive outcomes observed in primate models highlight the potential of this strategy.

A multicenter study has identified a potential new treatment for acute heart failure, a leading cause of hospitalization and death.

Life can be tough for young red squirrels living in the Canada's Yukon territory, where frigid winters, food scarcity and predators threaten their long-term survival. Scientists want to know what factors might protect young squirrels, especially as their environment becomes more impacted by climate change.

A team of researchers has identified a mechanism that causes mitochondrial dysfunction in Alzheimer's patients resulting in a reduction of the supply of energy to the brain.

Researchers have found that vitamin D encourages the growth of a type of gut bacteria in mice which improves immunity to cancer.

What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism. The findings could open up new avenues for the treatment of type 2 diabetes.

The antibiotic vancomycin, recommended as first-line treatment for infection caused by the deadly superbug C. difficile (C. diff), may not be living up to its promise, according to new research.

A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer's and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells -- with a potentially powerful therapeutic effect.

Researchers discovered liver resident macrophages' pivotal role in defending against gut bacteria and related substances entering via the portal vein, particularly under compromised intestinal barrier conditions. Identified as 'sentinel macrophages,' they are activated by isoallo-lithocholic acid. This finding holds promise for developing preventive and therapeutic strategies for liver chronic inflammatory diseases, such as metabolic dysfunction-associated steatohepatitis (MASH), by enhancing the function of these macrophages to mitigate inflammation and improve treatment efficacy.

A new study found certain genetic variants could help explain how long-term pesticide exposure could increase the risk of Parkinson's disease.

Machines can learn not only to make predictions, but also to handle causal relationships. An international research team shows how this could make therapies safer, more efficient, and more individualized.

Two of the biggest challenges faced by new and potential electric vehicle (EV) drivers are range anxiety and speed of charging, but these shouldn't have to be challenges at all. Researchers discovered that a change in refueling mindset, rather than improving the size or performance of the battery, could be the answer to these concerns.

Researchers have developed a web-based platform that offers an unprecedented view of the human body at the cellular level. The aim is to create an invaluable resource for researchers worldwide to increase knowledge about human health and disease.

Diagnosing rare Mendelian disorders is a labor-intensive task, even for experienced geneticists. Investigators are trying to make the process more efficient using artificial intelligence. The team developed a machine learning system called AI-MARRVEL (AIM) to help prioritize potentially causative variants for Mendelian disorders.

A study shows that investment by maternal grandmothers can improve the well-being of grandchildren who have faced adversities in life. The positive effects can last well into adulthood.

Researchers discovered that more than 300 liver genes are under circadian control: Circadian variations affect how much of a drug is available and how effectively the body can break it down.

Chemokines are signalling proteins that orchestrate the interaction of immune cells against pathogens and tumors. To understand this complex network, various techniques have been developed to identify chemokine-producing cells. However, it has not yet been possible to determine which cells react to these chemokines. Researchers have now developed a new class of genetically modified mice that enables the simultaneous identification of chemokine producers and sensors.

Warning letters can safely cut prescribing of a powerful but risky antipsychotic, according to a new study. Researchers used Medicare data to study the effects of the letters on hundreds of thousands of older adults with dementia. They found a significant and lasting reduction in prescribing but no signs of adverse effects on patient health.

Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.

People who take acid-reducing drugs may have a higher risk of migraine and other severe headache than people who do not take these medications, according to a new study. The acid-reducing drugs include proton pump inhibitors such as omeprazole and esomeprazole, histamine H2-receptor antagonists, or H2 blockers, such as cimetidine and famotidine, and antacid supplements.

To improve chemotherapy dosing, engineers designed CLAUDIA, a way to continuously measure how much drug is in a patient's system during hours-long infusion.

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer. Researchers have now uncovered for the first time how this exactly happens. The study provides rationales for new cancer immunotherapies and could make existing treatments more effective.

In a breakthrough for cancer research, scientists have created lab-grown mini-colons that can accurately mimic the development of colorectal tumors, offering a powerful new tool for studying and testing treatments for the disease.

Cleveland Clinic researchers developed an artficial intelligence (AI) model that can determine the best combination and timeline to use when prescribing drugs to treat a bacterial infection, based solely on how quickly the bacteria grow given certain perturbations. PNAS recently published their findings.

Conditions such as diabetes, heart attack and vascular diseases commonly diagnosed in people with spinal cord injuries can be traced to abnormal post-injury neuronal activity that causes abdominal fat tissue compounds to leak and pool in the liver and other organs, a new animal study has found.

Neuroscientists have revealed that recency bias in working memory naturally leads to central tendency bias, the phenomenon where people's (and animals') judgements are biased towards the average of previous observations. Their findings may hint at why the phenomenon is so ubiquitous.

A new study has discovered how a lipid molecule found at high levels within tumors undermines the anti-cancer immune response and compromises a recently approved immunotherapy known as adoptive cell therapy (ACT) using tumor infiltrating lymphocytes, or TIL-ACT.

A groundbreaking study combined novel experimental data within an innovative modeling framework to examine how temperature might affect transmission risk of malaria in different environments in Africa.

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

A thin film that combines an electrode grid and LEDs can both track and produce a visual representation of the brain's activity in real-time during surgery -- a huge improvement over the current state of the art. The device is designed to provide neurosurgeons visual information about a patient's brain to monitor brain states during surgical interventions to remove brain lesions including tumors and epileptic tissue.

A university professor has found a way to help students -- and himself -- power through long lecture classes: exercise breaks. A new study showed that five-minute exercise sessions during lectures were feasible and that students reported positive impacts on their attention and motivation, engagement with their peers and course enjoyment.

A new national survey finds a broad majority of parents experience isolation, loneliness and burnout from the demands of parenthood, with many feeling a lack of support in fulfilling that role.

The beginning of life is shrouded in mystery. While the intricate dynamics of mitosis is well-studied in the so-called somatic cells -- the cells that have a specialized function, like skin and muscle cells -- they remain elusive in the first cells of our bodies, the embryonic cells. Embryonic mitosis is notoriously difficult to study in vertebrates, as live functional analyses and -imaging of experimental embryos are technically limited, which makes it hard to track cells during embryogenesis.

Cognitive decline among Black women linked to poor heart health in middle age.

A new computer process makes it possible to generate active pharmaceutical ingredients quickly and easily based on a protein's three-dimensional surface. The new process could revolutionize drug research.

A brain circuit inhibits food intake during nausea.

New research has highlighted the profound link between dietary choices and brain health.

A study has now successfully controlled the effects of collagen hypersecretion at the cellular level. The experimental treatment consists of designer peptides which interrupt the interaction between TANGO1 and cTAGE5, two proteins important for collagen secretion. Experiments with patient-derived human cells and zebrafish showed the peptides are effective, non-toxic, and their effects reversible. The results pave the way for the development of new treatments that improve the cosmetic effects of scarring, relieve the symptoms of autoimmune diseases such as scleroderma, or help prevent the development of fibrosis, a more serious condition attributed to 45% of deaths in the industrialized world.

Researchers have published results of a phase I clinical trial of a novel immunotherapy for high-risk sarcomas.

The emergence in the Neolithic of patrilineal social systems, in which children are affiliated with their father's lineage, may explain a spectacular decline in the genetic diversity of the Y chromosome observed worldwide between 3,000 and 5,000 years ago.

Researchers have found that people following healthy eating accounts on social media for as little as two weeks ate more fruit and vegetables and less junk food.

Researchers have created a new vaccine candidate to treat staph and MRSA infections.

New research has found a significant association between participating in low to moderate intensity exercise and reduced rates of depression.

If a patient is successfully resuscitated after a cardiac arrest and circulation resumes, they are not out of the woods yet. A number of factors can influence whether and how they survive the trauma in the subsequent phase. The administration of the anaesthetic midazolam has a positive effect, as shown by a multicenter study of 571 patients.

A computer game helped upper secondary school students become better at distinguishing between reliable and misleading news.

The enzyme PI3K plays a critical role in cell migration. Scientists have long understood this function. But researchers have recently unveiled that a subunit of this enzyme also has the ability to slam on the breaks to this process.

Researchers have developed a method to determine how reliably target proteins can be labeled using super-resolution fluorescence microscopy.

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

Nursing homes in disadvantaged communities are more likely to overmedicate residents with antipsychotics, especially homes that are understaffed, according to a new study.

Study identifies key pathways underlying perianal fistula, a disease complication that is more prevalent and severe in African American populations.

A study has sampled single live cancer cells and measured the fatty lipid compounds inside them. The team saw how those cells transformed in response to changes in their environment.

Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk. Learn how ancestry changes genetic risk variants' impact on type 2 diabetes in childhood cancer survivors & alkylating agent exposure magnifies diabetes risk.

Researchers have developed a new tool to better understand how chemicals like dopamine and epinephrine interact with neurons.

Psychologists have found that people are as hesitant to reach out to an old friend as they are to strike up a conversation with a stranger, even when they had the capacity and desire to do so.

A team of researchers found that long-tie connections accelerate the speed of social contagion.

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

An assistant professor conducted a study in which he lived among one of the poorest, most marginalized communities in Seoul, South Korea. In the ethnographic study, he asked residents how they dealt with extreme heat. He found they tended to accept the conditions, stating there was not much that could be done. That shows people accepted extreme climate events, despite evidence showing this should not be normal, which bodes the argument social work as a field has much to do to help address climate emergencies.

A new study highlights the lasting financial impact of a cancer diagnosis for many working-age adults and their families in the United States. It shows a cancer diagnosis and the time required for its treatment can result in employment disruptions, loss of household income and loss of employment-based health insurance coverage, leading to financial hardship.

Using state-of-the-art microscopy techniques, researchers have shed new light on the underlying mechanisms driving Alzheimer's disease.

Researchers find less Salmonella on backyard poultry farms. But concerns remain about the prevalance of multidrug-resistant bacteria on both large and small farms.